Handara, G., Hetsch, F.J.A., Jüttner, R., Schick, A., Haupt, C., Rathjen, F.G., and Kröger, S. Acetylcholine receptors in the equatorial region of intrafusal muscle fibres modulate mouse muscle spindle sensitivity. Gerwin, L., Haupt, C., Wilkinson, K.A., and Kröger, S. (2020) Impaired Muscle Spindle Function in Murine Models of Muscular Dystrophy.
Gerwin, L., Rossmanith, S., Haupt, C., Schultheiß, J., Brinkmeier, H., Bittner, R.E., Kröger, S. Molecular and cellular basis of synapse formation pathological changes at the neuromuscular junction and in the developing CNS role of the synapse organizer agrin at the neuromuscular junction and in the CNS muscle spindle structure, function and development in wildtype and dystrophic mice Since 2007 Professor for Neurophysiology at the Biomedical Center (Medical School), Ludwig-Maximilians-University, Munich These results show alterations in muscle spindle afferent responses in dystrophic mouse muscles, which might cause an increased muscle tone, and might contribute to the unstable gait and frequent falls observed in patients with muscular dystrophy.ġ979 – 1984 Studies of Biochemistry at the University of Tübingenġ984 – 1986 masters work at the Max-Planck-Institute for Developmental Biology, Tübingenġ986 – 1989 PhD thesis at the Max-Planck-Institute for Developmental Biology, Tübingen.ġ989 – 1992 Postdoctoral fellow at the Department of Neurobiology, Stanford University School of Medicine.ġ992 – 2000 Head of an independent research laboratory at the Max-Planck-Institute for Brain Research, Frankfurt.Ģ000 – 2006 Group leader at the Institute for Physiological Chemistry at the University of Mainz (Faculty of Medicine).Ģ006 – 2007 Associate Professor for Molecular Cell Biology at the University of Applied Sciences in Senftenberg
In contrast, the response to ramp-and-hold stretches appeared mostly unaltered compared to the respective wildtype mice. Single-unit extracellular recordings of sensory afferents from muscle spindles of the extensor digitorum longus muscle revealed that muscle spindles from both dystrophic mouse strains have an increased resting discharge and a higher action potential firing rate during sinusoidal vibrations. Utrophin was substantially upregulated in dystrophin-deficient mice, suggesting a potential compensatory activity of utrophin in DMDmdx mice. Immunohistochemical analyses of wildtype muscle spindles revealed a concentration of dystrophin and b-dystroglycan in intrafusal fibers outside the region of contact to the sensory neuron. The total number and the overall structure of muscle spindles in soleus muscles of the dystrophic mice appeared unchanged, demonstrating that intrafusal fibers are less affected by the degeneration compared to extrafusal fibers. dystrophin- (DMDmdx) and dysferlin-deficient mice. To investigate, if proprioception is affected in dystrophic muscles, we analyzed muscle spindle number, morphology and function in wildtype mice and in murine models for two distinct types of muscular dystrophy with very different disease etiology, i.e. For example, in muscular dystrophies (MD), patients often experience sudden spontaneous falls, balance problems, as well as gait and posture abnormalities, suggesting the possibility of an impaired muscle spindle function. In many neuromuscular diseases, movement is impaired, although the mechanism remains elusive. Muscle spindles are the primary proprioceptive sensory receptors and are present in almost all skeletal muscles.
information about muscle tone as well as position and movement of the extremities in space. 13th february : 1.30 pm to 3 pm , amphitheater BabinskiĬoordinated movements, including locomotion, and their control, require proprioceptive information, i.e.
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